Objective To explore mental health status and evaluation of mental intervention effect in pa-tients with chronic hepatitis B (CHB) .Methods A total of 190 CHB patients were assigned to research group and 65 ones with general chronic diseases to control group .Mental health levels were assessed with the Symptom Checklist-90 (SCL-90) for both groups at baseline ;research group received purposeful men-tal interventions ,their qualities of life were assessed with the WHO Quality of Life Scale-BREF (WHO-QOL-BREF) at baseline and discharge .Results The total ,somatization ,obsession ,interpersonal rela-tion ,depression and anxiety score were all significantly higher in research than control group (P<0 .05 or 0 .01) ,emotional features were dysphoria ,anxiety ,phobia ,pessimism/disappointment ,depression and so on . Physiological , psychological , social and environmental domain score of the WHOQOL-BREF heightened more significantly after intervention compared with pre-intervention in research group ( P<0 .01) .Conclusion CHB patients have different degrees of psychological problems ,their psychological problems are severer compared with patients with general chronic illness ,purposeful mental intervention could effectively relieve patients’ negative emotions and improve quality of life .%目的：探讨慢性乙型肝炎患者的心理健康状况及心理干预效果。方法将190例慢性乙型肝炎患者设为研究组，65例普通慢性疾病患者设为对照组。入组时采用症状自评量表评定两组患者的心理健康状况；研究组患者接受有针对性的心理干预，于入组时及出院时采用世界卫生组织生存质量测定简表评定生活质量。结果研究组症状自评量表总分及躯体化、强迫、人际关系、抑郁、焦虑因子分显著高于对照组（ P＜0．05或0．01）；情绪特征表现为烦躁不安、焦虑、恐惧、悲观失望、抑郁等情绪问题。心理干预后研究组患者世界卫生组织生存质量测定简表生理领域、心理领域、社会关系领域及环境领域因子分均较心理干预前显著升高（P＜0．01）。结论慢性乙型肝炎患者存在不同程度的心理问题，且较普通慢性疾病患者更严重，对其予以有针对性的心理干预后能有效缓解患者的负性情绪，提高患者的生存质量。
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