儿童期精神分裂症患者认知功能研究

摘要

目的：探索儿童期精神分裂症患者认知功能情况。方法：对12名年龄≤16岁以妄想为主要症状的精神分裂症患者（患者组）及12名正常匹配儿童（对照组）进行认知功能测验（包括听觉词汇学习、数字广度、数字符号及瑞文标准推理测验）。结果：患者组在听觉词汇学习、数字广度、数字符号及瑞文标准推理测验成绩均较对照组差。其中，知觉辨别的效应值最大为-2.10，其次为比较推理-1.68、抽象推理-1.29、即刻记忆-1.20、数字符号-1.44、系列关系-0.82、数字广度（倒背、正背）分别为-0.77，-0.28、类同比较-0.30、延迟记忆保持率的效应值为0.32。结论：儿童期精神分裂症患者在智能、逻辑推理、记忆功能、注意功能、执行功能等方面均有不同程度的损害。%Objective:To explore the cognitive function of patients with childhood schizophrenia. Method:12 patients with childhood schizophrenia with the main symptom of delusion(case group)and 12 nor-mal children(control group)were assessed by neuropsychological tests(including auditory verbal learning test, digital span test,digital symbol test and Raven standard reasoning test). Results:The results of the tests of auditory verbal learning,digital span,digital symbol and Raven standard reasoning test in case group were worse than control group. The largest effect size of perceptual discrimination was - 2. 10. Then,the effect size of com-parison of reasoning,abstract reasoning,immediate memory,digital symbol,relation series,digital span,compari-son of class and delayed memory probability were - 1. 68,- 1. 29,- 1. 20,- 1. 44,- 0. 82,- 0. 77,- 0. 28,- 0. 30,0. 32. Conclusion:To different degrees intelligence,logical reasoning,memory,attention,executive function are impaired in patients with childhood schizophrenia.