肉眼血尿对尿液化验结果的影响

摘要

Objectives To explore the effects of gross hematuria on the results of several parmeters in laboratory urine examination. Methods Eighty (80) children with IgA nephropathy and 40 cases with acute post-streptococcal glomerulonephritis hospitalized in our hospital from January 2014 to December 2015 were recruited. The ratio of urinary calcium and protein to creatinine, quantitative test of 24 h urinary calcium and protein, quantitative test of 24 h urinary albumin,α1-microglobulinuria, microalbuminuria and urine protein electrophoresis were tested during and after the gross hematuria, respectively. Results The ratio of urinary calcium and protein to creatinine, quantitative test of 24 h urinary calcium and protein were much higher in the duration of gross hematuria as compared to those after the duration of gross hematuria, while α1-microglobulinuria, microalbuminuria and quantitative test of 24 h urinary albumin showed no difference between the two periods. Conclusions Gross hematuria could increase the level of urinary calcium and protein, while quantitative test of 24 h urinary albremin is not affected.%目的 探讨肉眼血尿对尿液多项化验检查结果 的影响.方法 回顾分析比较2014年1月至2015年12月间收治的80例有明显肉眼血尿的IgA肾病(IgAN)患儿、40例急性链球菌感染后肾小球肾炎(APSGN)患儿,分别在肉眼血尿期间、肉眼血尿消失后送检尿常规、尿蛋白定量、尿白蛋白定量、尿蛋白/肌酐、尿钙定量、尿钙/肌酐、肾早期损伤指标和尿蛋白电泳的变化情况.结果 IgAN和APSGN两组患儿在肉眼血尿期间的尿蛋白定量、尿蛋白/肌酐、尿钙定量、尿钙/肌酐和尿小分子蛋白百分比水平较肉眼血尿消失后明显升高,差异均有统计学意义(P均<0.05);而尿白蛋白定量、肾早期损伤各指标(如微量白蛋白、α1微球蛋白水平、N-乙酰-β-D-葡萄糖苷酶)、血钙/肌酐、尿白蛋白百分比水平与肉眼血尿消失后比较,差异均无统计学意义(P均>0.05).肉眼血尿期间,IgAN和APSGN两组患儿的尿蛋白定量水平均高于尿白蛋白定量水平(P<0.001);而肉眼血尿消失后,两组患儿的尿蛋白定量与尿白蛋白定量水平之间的差异均无统计学意义(P>0.05).结论 肉眼血尿时尿蛋白、尿钙定量结果 均偏高,而尿白蛋白定量则不受影响.