急性脑梗死患者血清脂蛋白相关磷脂酶A2水平的改变及其与病情的关系

摘要

Objective To research the change of serum level of lipoprotein phospholipase A2 ( Lp-PLA2) and its relation with the condition in patients with acute cerebral infarction ( ACI). Methods Acording to the national institute of health stroke seale (NIHSS) scores, 91 ACI patients were divided into the mild ACI group ( NIHSS < 4) , moderate ACI group (4 ~ 15) and severe ACI group ( > 15). Meanwhile, the levels of LP-PLA2 were detected in the ACI patients and 31 normal controls by enzyme linked immunosorbent assay. The relationship between the NIHSS score and serum LP-PLA2 level in ACT patients was analyzed by Spearman correlation analysis. Results The level of serum LP-PLA2 in ACI group was significantly higher than that in the normal control group ( P < 0. 01). The level of serum LP-PLA2 in the severe ACI subgroup was significantly higher than that in the mild and moderate ACI subgroups ( all P <0. 01). The NIHSS scores was positive correlated with the level of serum LP-PLA2 in ACI patients by Spearman correlation analysis ( r = 0. 485, P < 0. 001 ). Conclusions The level of serum LP-PLA2 is significantly increased in ACI patients. The more severer the pathogenetic condition is, the more higher the level of serum LP-PLA2.%目的 研究急性脑梗死(ACI)患者血清脂蛋白相关磷脂酶A2(LP-PLA2)水平的改变及其与病情的关系.方法 91例ACI患者按照美国国立卫生研究院卒中量表(NIHSS)评分分为轻型ACI组(NIHSS评分＜4分)、中型ACI组(4～15分)、重型ACI组(＞15分).应用酶联免疫吸附法测定ACI患者及31名正常对照者的血清LP-PLA2水平.ACI患者NIHSS评分与血清LP-PLA2水平的关系用Spearman相关分析.结果 ACI组的血清LP-PLA2水平显著高于正常对照组(P＜0.01)；重型ACI亚组血清LP-PLA2水平又显著高于中型ACI亚组和轻型ACI亚组(均P＜0.01).经Spearman相关分析,ACI患者的NIHSS评分与血清LP-PLA2水平呈正相关(r=0.485,P＜0.001).结论 ACI患者的血清LP-PLA2水平显著升高,病情越重者升高越明显.