阿司匹林联合氯吡格雷对脑梗死患者同型半胱氨酸、超敏C反应蛋白的影响及预后分析

摘要

Objective To analyze the effects of aspirin combined with clopidogrel on Hcy and hs-CRP in patients with cerebral infarction.Methods A total of 69 patients with cerebral infarction in our hospital were divided into two groups,patients in observation group with 39 cases were treated with aspirin combined with clopidogrel,and control group with 29 cases treated with aspirin.The therapeutic effects of two groups,the changes of serum Hcy,hs-CRP and NIHSS scores before and after treatment were observed.Results Hcy and hs-CRP levels were significantly decreased in the observation group and the control group after seven days of treatment.However,the observation group was significantly lower.After treatment,NIHSS score decreased in both groups,however,there was no significant difference in NIHSS in two groups.The ESS and ADL score were significantly improved,and observation group was better than the control group after 21 days of treatment(P ＜0.05).Conclusion Aspirin combined with clopidogrel can significantly reduce serum Hcy and hsCRP levels,and improve the prognosis in patients with cerebral infarction.%目的 观察阿司匹林联合氯吡格对脑梗死患者血清同型半胱氨酸、超敏C反应蛋白的影响及预后疗效评价.方法 选取急性脑梗死患者68例.观察组39例给予阿司匹林联合氯吡格雷口服;对照组29例给予阿司匹林口服.观察2组患者治疗效果、治疗前后血清同型半胱氨酸、超敏C反应蛋白的变化情况及2组患者治疗前后神经缺损功能NIHSS评分.结果 2组患者治疗7d后Hcy及hs-CRP均明显下降,且观察组患者降低更为明显.2组患者治疗后NIHSS评分均下降,但2组NIHSS分值并无显著差异.在临床治疗21 d后,2组患者ESS、ADL评分均有显著改善,且观察组脑梗死改善程度显著优于对照组(P＜0.05).结论 阿司匹林联合氯吡格雷可以显著降低脑梗死患者血清同型半胱氨酸及超敏反应C蛋白水平,改善患者预后.