Objective To investigate the diagnostic methods in adult growth hormone deficiency ( AGHD) . Method Using the method of dynamic function test trials with insulin, arginine and L-dopa as the stimulis of stimulation test respectively. 56 adult patients with sellar diseases were recruited from October 2008 to December 2010 in our hospital. Insulin tolerance test (ITT) was performed in 26 cases,and the other 30 cases received arginine and L-dopa test for detection of growth hormone. Synthesis, secretion and reserve function of growth hormone in adult sellar pituitary were evaluated. Results In ITT,arginine and L-dopa stimulation test,the GH peak were 0. 52 ±0. 88 ng/ml,0. 28 ±0. 46 ng/ml and 0. 10 +0. 09 ng/ml, respectively, less than 3 ng/ml. No statistically significant difference was found between arginine or L-dopa stimulation test and the ITT test. Conclusions Severe growth hormone deficiency disease is common in saddle diseases. Compared with ITT test, arginine or L-dopa stimulation test did not show significant difference,they are safe,and can be detection methods of AGHD in clinic.%目的 探讨成人生长激素缺乏症(AGHD)的诊断方法.方法 选择2008年10月～2010年12月在我院就诊的成人鞍区疾病患者56例,26例患者采用胰岛素耐量试验,另30例患者先后行精氨酸和左旋多巴试验检测生长激素,探测成人鞍区疾病患者腺垂体生长激素合成与分泌储备功能.结果 胰岛素耐量试验、精氨酸和左旋多巴兴奋试验中,生长激素峰值分别是(0.52±0.88) ng/ml、(0.28±0.46) ng/ml和(0.10±0.09) ng/ml,均＜3 ng/ml.精氨酸和左旋多巴兴奋试验与胰岛素耐量试验比较差异无统计学意义(P＞0.05).结论 鞍区疾病患者普遍存在严重生长激素缺乏,精氨酸兴奋试验、左旋多巴兴奋试验与胰岛素耐量试验比较差异无统计学意义,安全性好,可作为成人生长激素缺乏症的检测方法.
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