Kupffer细胞在肝纤维化发生过程中的双向调节作用

摘要

The underlying mechanisms of liver fibrosis have not yet been fully elucidated. Studies with models of toxic or cholestatic liver fibrosis have implicated Kupffer cells, the largest group of resident liver macrophages, as playing a critical role in the pathogenic process. Kupffer cell receptor activation, cytokine expression, and phenotype may contribute to the onset or progression of liver fibrosis. Pro - fibrotic cytokines, such as transforming growth factor βl , platelet -derived growth factor and anti -fibrotic matrix metalloproteinase 13, are known to play a pivotal role in both fibrogenesis and fibrolysis. In this review, we discuss the known functions and dynamic molecular processes of Kupffer cells during liver fibrosis to provide further insights into the underlying pathogenic mechanisms of this disease.%肝脏纤维化的发生机制尚不完全明确,研究发现肝内巨噬细胞(Kupffer细胞)在肝纤维化发生发展过程中发挥重要作用.Kupffer细胞主要通过受体介导及细胞因子表达和分型变化影响纤维化形成;分泌促纤维化的转化生长因子(TGF) β1和血小板衍生生长因子(PDGF),或促纤维降解的基质金属蛋白酶-13等,导致Kupffer细胞在不同纤维化阶段发挥不同的调节肝纤维化的作用,本文综述Kupffer细胞在肝纤维化发生过程中双向调节作用,以期为肝纤维化的研究提供新的临床思路.