不孕症患者促甲状腺素水平变化对 IVF/ICSI - ET 结局的影响

摘要

Objective To investigate the effects of thyroid stimulating hormone( TSH)levels for in vitro fertilization/ intracytoplasmic sperm injection - embryo transfer(IVF/ ICSI - ET)outcome in infertility. Methods 69 patients with infertility undertaken IVF/ ICSI treatment were divided into low TSH group(≤2. 5 mU/ L )(n = 29)and patients with 2. 5 mU/ L 2. 5 mU/ L )(n = 23). Effect of TSH levels on IVF / ICSI - ET outcomes was compared. Results In treatment non - success group,the number of fertilized eggs,normal fertilization rate and cleavage rate had no significant difference with treatment success group and low TSH group. But the high quality embryos,implantation rate,clinical pregnancy rate and early abortion rate were significantly lower than the treatment success group and the low TSH group. Conclusion For infertile patients with 2. 5 mU/ L 2.5 mU/ L 且≤5.0 mU/ L 的患者（n =40）进行左旋甲状腺素片预治疗。治疗后，TSH 0.05），但优质胚胎数、胚胎种植率、临床妊娠率和早期流产率显著低于治疗成功组和低 TSH组。结论对于2.5 mU/ L < TSH≤5.0 mU/ L 的不孕患者应积极治疗，降低 TSH 水平，对改善 IVF/ ICSI - ET 结局具有重要意义。