Objective To compare the efficacy of acupotomy combined with oral administration of non - steroid anti - inflammatory drugs versus oral application of non - steroid anti - inflammatory drugs alone in treatment of knee osteoarthritis(knee osteoarthritis,degenerative arthritis of knee). Methnds A total of 120 patients with osteoarthritis of knee were randomly divided into two groups(groups A and B),each with 60 pa-tients. Patients in group A were oral administrated with non - steroid anti - inflammatory drugs,while patients in group B were applied with minimally invasive acupotomy combined with oral administration of non - steroid anti - inflammatory drugs. WOMAC scores and clinical outcomes were com-pared between these two groups at the end of treatment,1 month,3 months and 6 months after the treatment. Results There was no statistical differ-ence in WOMAC scores between these two groups before treatment,at the end of treatment and 1 month after the treatment;but the WOMAC scores were higher in Group B at 3 and 6 months after the treatment,and the difference was statistically significant. The clinical effect was compared at the end of treatment and 1,3 and 6 months after the treatment,the rates of efficiency in patients of group A were 83. 3% ,78. 3% ,53. 3% and 48. 3%respectively,and the rates of efficiency in patients of group B were 90. 0% ,85. 0% ,81. 7% and 85. 0% respectively. With the extension of time af-ter treatment,the rate of efficiency in patients of group A was gradually reduced,and the difference was statistically significant(trend χ2 =21. 377, P =0. 000),the change in rate of efficiency in patients of group B was not significant,and the difference was not statistically significant(trend χ2= 0. 458,P =0. 498). The rates of efficiency in patients of group B were significantly higher in 3 months and 6 months after the treatment than those in patients of group A( P <0. 01). Cniclusini Minimally invasive treatment with combination of acupotomy and oral administration of non - ster-oid anti - inflammatory drugs is significantly more effective than oral administration of non - steroid anti - inflammatory drugs alone.%目的：比较针刀联合口服非甾体类消炎药与单纯口服非甾体类消炎药治疗膝骨关节病（膝骨关节炎、退行性膝关节炎）的临床疗效。方法将120例膝骨关节炎顽固性疼痛患者随机分为口服非甾体类消炎药治疗组（ A组），中西医结合针刀微创疗法治疗组（B 组），每组60例。比较两组在疗程末、1个月、3个月、6个月的 WOMAC 评分，以及临床疗效。结果两组 WOMAC 评分，在治疗前、治疗末及治疗1个月，差异无统计学意义（ P >0.05）；但在治疗后3个月和6个月，B 组均高于 A 组，差异均有统计学意义（ P <0.05）。临床疗效比较，在治疗末及治疗后1、3 和6个月各时间点的治疗有效率，A 组分别为83.3%、78.3%、53.3%和48.3%，B 组分别为90.0%、85.0%、81.7%和85.0%，随着治疗结束后时间的延长，A 组治疗有效率逐渐降低，差异有统计学意义（趋势χ2=21.377，P =0.000），B 组治疗有效率变化不明显，差异无统计学意义（趋势χ2=0.458，P =0.498）。在治疗后3个月和6个月 B 组治疗有效率均高于A 组，差异均有统计学意义（ P <0.01）。结论针刀微创疗法联合口服非甾体类消炎药治疗膝骨关节炎顽固性疼痛的长效作用明显优于单纯非甾体类消炎药。
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