质子泵抑制剂与胃癌风险性病理生理机制及临床研究进展

摘要

质子泵抑制剂作为一种制酸药物广泛应用于临床,然后在全球范围内存在过度使用,虽总体安全有效,但有研究显示其潜在远期不良反应存在不确定性,尤其是与致胃癌机制的联系.临床医生应意识到长期质子泵抑制剂治疗存在致癌潜在风险,现将有关质子泵抑制剂致胃神经内分泌肿瘤、胃腺癌、胃贲门癌的病理生理假设机制和临床依据及建议总结如下.%Proton pump inhibitors as a kind of acid drug are widely used in clinical.However,it is overused all over the world although generally safe and effective.Studies have shown the uncertainty of potential long-term adverse effects,especially the contact with the mechanism of gastric cancer.Clinicians should pay more attention to the potential carcinogenic risk of long-term proton pump inhibitors in treatment.The mechanism of pathophysiology and the clinical researches of proton pump inhibitor-induced gastric neuroendocrine tumors,gastric carcinoma,and gastric cardia cancers are summarized as follows.