四苯硼钠法测定氯氮(艹卓)的含量

摘要

This paper describes an effective method for determining chlordiazepoxide. An excess of sodium tetraphenylboron is added to precipitate chlordiazepxide in HAc-NaAc buffer solution (pH = 4.0). After filtering off the precipitate,the excessive sodium tetraphenylboron in the filtrate is titrated with cetyltrimethylammonium bromide standard solution, with bromophenol blue as indicator. The method is simple and rapid, it has been applied for the determination of chlordiazepoxide raw materials with satisfactory results. The recovery is between 99.58% and 100.4%, the relative error is less than ±0.50%. Experiments show that the method gives the same results as the approach using nonaqueous tirtation (ChP).%本文介绍一种可有效地测定氯氮(艹卓)含量的方法.在pH=4.0的HAc-NaAc缓冲溶液中,加入过量的四苯硼钠与氯氮(艹卓)反应可形成分子比为1:1的定量沉淀,过滤,弃去初滤液.以溴酚蓝为指示剂,用十六烷基三甲基溴化铵标准溶液滴定续滤液中过量的四苯硼钠,方法简便快速,应用于多批氯氮(艹卓)原料药样品的测定,其回收率为99.58%～100.4%,相对误差＜±0.50%,与中国药典法测得的结果基本一致.