Lornoxicam (6-chloro-4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno-[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide)is persist as a non-steroidal anti-inflammatory drug of the oxicam class with analgesic,anti-inflammatory and antipyretic properties.A fast,accurate and sensitive chromatographic method for estimation of Lomoxicam was developed as no official method available for detection.The chromatographic separation employs isocratic elution by utilizing an inertsil ODS-C18,250 mm×4.6 mm,5 μm columns.Mobile phase consisting of solvent (40 mL acetonitrile and 60 mL 0.1 M phosphate buffer (pH 6.8 was adjusted with triethylamine)) endowed at a flow rate of 1.0 mL/min.The analyte was detected and quantified at 290 nm using UV detector.The method was validated according to ICH guidelines,illustrating to be accurate (recovery 99.08％-101.13％) and precise (intraday (0.27-1.32) and interday (0.59-1.59))within the corresponding linear range (10-60 μg/mL) with r2 0.9992.
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