Localization of X-gene translation product in human cholangiocarcinoma and its surrounding liver tissues

摘要

Intrahepatic cholangiocarcinoma is an uncommon type of primary hepatomaand its mechanism is still unknown.Twenty samples of the cancer and the surrounding tis-sues were all taken from the Xi’an area and examined for the presence of X-gene prod-uct(HBxAg)by the avidin-biotin-peroxidase complex method.It was found that 17 cases(85%)showed positive reaction,HBxAg was present in 15 cancer samples and 16non-tumor tissue samples.This result suggests that there is a close relationshipbetween human cholangiocarcinoma and HBV,and the HBxAg might play an importantrole in the pathogenesis of cholangiocarcinoma.