Experimental St■■■es on the Mutagenicity of Hydroxypiperaquine Phosphate

摘要

The mutagenicity of hydroxypiperaquine phosphate (HPQP) was detected by a battery of assays including Amestest, chromosomal aberration test in vitro, micronucleus testand dominant lethal test The results obtained have shownthe absence of mutagenicity of HPQP up to the inhibitoryconcentration to Salmonella typhimurium TA97a. TA98.TA100 and TA102 with or without S-9 mix. The