Measurement of individual hypoxic sensitivity by means of mouth occlusion pressure

摘要

mouth occlusion pressure (P0.1) rather than inspiratory ventilation （V1）and mean inspiratory airflow （（?）） was used for expounding the mechanism of indi-vidual hypoxic sensitivity.Eighteen young healthy male subjects participated inthe experiment of progressive isocapnic hypoxia produced by rebreathing method.The results showed that there were significantly linear relationship （P0.01） be-tween V1 and P0.1,as well as （?） and P0.1 during the hypoxic loading of twoend-tidal carbon dioxide pressure (PETCO2 levels,4.3 and 5.9kPa.Ventilation in-creased with progressive hypoxia.Therefore,they all represent the useful indexesof inspiratory drive.P0.1 is more sensitive than V1 and （?） because it isindependent of pulmonary mechanics.