Changes and clinical significance of plasma levels of carbon monoxide and nitric oxide in perinatal asphyxi al neonates

摘要

Objective:To studythechangesof plasmalevelsof carbonmonoxide(CO)andnitricoxide(NO)in asphyxial neonates.Methods:PlasmaCO andNO levelsof33perinatalasphyxialneonatesand30healthynewborninfantswere measured.Results:TheplasmaCOandNOlevelswerecloselycorrelatedto theoccurrenceandclinicalseverityof hypoxic-ischemicencephalopathy(HIE).TheperinatalasphyxialpatientswithHIEhadsignificantlyhigherCO andNO levelsthan thosewithoutHIEandthenormalcontrols(P0.05).Moreover,inthe caseswithHIE,theCO andNO levelswerecorrelatedto theseverityof clinicalmanifestations,thatis,thehighertheCO andNOlevels,themoreseveretheclinicalmanifestationsare(P<0.05).Conclusion:Inadditionto NO,CO is anotheren-dogenousmediatorwhichplaysan importantroleintheoccurrenceof HIEinperinatalasphyxialneonates.