Department of Cardiology;
Zhujiang Hospital;
First Military Medical University;
Guangzhou 510282;
China;
Instisute of Cardiology;
First Hospital;
Beijing University;
Beijing 100034;
China;
Department of Cardiology;
Zhujiang Hospital;
First Military Medical University;
Guangzhou 510282;
Chinabjective: To understand the role of urotensin Ⅱ( U Ⅱ) and proadrenomedullin N-terminal 20 peptide ( PAMP);
a fragment of proadrenomedullin ( proADM ) possessing biological activity;
in the pathophysiological process of congestive heart failure (CHF) by observing the variation of their plasma levels and exploring their interrelations. Methods: Plasma U Ⅱand PAMP levels were measured by radioimmunoassay in 52 patients with CHF and 14 healthy subjects. Left ventricular ejection fraction (LVEF) and the ratio of E/A were determined by echocardiography. Results: The plasma U Ⅱlevel was significantly lower in patients with CHF than the healthy subjects (1.5±1.0 pg/ml vs 4. 3±1.2 pg/ml;
P < 0.05);
while plasma PAMP level was significantly higher in the former group (30. 6±5. 8 pg/ml vs 21.0±6.6 pg/ml P < 0. 05 ). The levels of U Ⅱand PAMP were parallel with the severity of CHF;
and significant correlation of plasma levels of U Ⅱwith LVEF (r=0.530;
P=0.000) and the ratio of E/A (r=0.618;
P = 0. 000) was noted. LVEF and ratio of E/A were found to be inversely correlated with plasma PAMP levels in the patients ( r = - 0. 568;
P = 0. 000;
r = - 0. 350;
P ?0. 004 ) . Also found was the significant correlation between plasma U Ⅱand PAMP levels (r= -0.528;
P = 0. 000) . The treatment of the patients resulted in increased plasma U Ⅱlevels and lowered PAMP levels. Conclusion: The variations of plasma levels of U Ⅱand PAMP are parallel with the severity of CHF;
suggesting their cooperative actions in the pathophysiology of CHF.;
充血性心力衰竭; 乌洛腾生Ⅱ; PAMP; 左心室射血分数;