Experiment study of Swainsonine's antineoplastic activity

摘要

ED50 of Pure Swainsonine (SW) to EMT6 cell strain is 1.2 (0.8-1.6) mg/L and the dose of entire lethal is 6.4 mg/L with MTT method. After ig crude extraction of SW to S180 sareoma rooted in mouse and EMT6 model mice with breast carcinoma for 12 d at dose of 16 mg/kg, the inhibitory rates of weight amounts to 49.7% and 49.4% respectively (P<0.01). Given crude extraction of SW at 4 mg/kg combined with irradiation at 5 Gy60Co-γ, the inhibitory rate of weight of S180 amount to 64.5% (P<0.01). It shows that SW has obviously antineoplastic.