Serum level of MMP-2,MMP-9 and Ox-LDL in Alzheimer's disease with hyperlipoidemia

摘要

Objective:To investigate serum levels of MMP 2,MMP-9.oxidized low-density lipoprotein (ox-LDL) in Alzheimer's disease(AD) patients and study the possible pathway and mechanism of AD with abnormal lipid metabolism.Methods:Subjects in this study were divided into 4 groups:normal lipid group without AD(N),hyperlipoidemia group without AD(H).normal group with AD(A),hyper- lipoidemia group with AD(AH).There were 15 individuals in each group.MMP-2,MMP 9,ox-LDL was measured by enzyme linked immunosorbent assay(ELISA).Serum lipids levels were measured by biochemical methods.Results:The serum levels of MMP-2.MMP-9,ox-LDL were significantly higher in H.Aand AH groups than those in N group.Those of ox-LDL in H.AH groups was higher than that of in A group.The serum level of MMP 2,MMP-9 in AH groups were higher than that of in H group.The score of mini mental state examination (MMSE) in A and AD groups was negatively correlated with the serum level of ox-LDL.Relationship between the score of MMSE and the serum level of ox-LDI,in AD groups and non-AD groups had statistical significance.Conclusion:MMP-2,MMP-9,ox-LDL and abnor real lipid metabolism may participate in pathogenesis of AD,in which abnormal lipid metabolism induces expressions of MMP-2 ,MMP-9 and ox-LDL.Oxidative stress and blood-brain barrier disruption mighl ac- celerate the process of AD.