三种外用药物预防5-氟尿嘧啶持续泵入所致外周化疗性静脉炎的临床效果

摘要

Objective To investigate the clinical efficacy of Hiru doid,Sufu and Musk Hemorrhoids Ointment on preventing peripheral chemothera⁃peutic phlebitis due to continuous infusion of 5⁃fluorouracil. Methods Totally 90 patients with esophageal squamous cell carcinoma treated with continuous infusion of 5⁃fluorouracil were recruited and randomly divided into Hirudoid group,Sufu group and Musk Hemorrhoids Ointment group, with 30 cases in each group. Three groups were applied with drugs respectively along the vein punctured while connecting the pump of 5⁃fluorouracil 3 times a day(each time interval of 6 hours)for 5 consecutive days. The occurrence of chemotherapy phlebitis was observed and recorded. Results Musk Hemorrhoids Ointment and Sufu were more effective than Hirudoid in reducing the incidence of phlebitis and relieving the degree of venous in⁃jury(P<0.05);however,there were no differences between Musk Hemorrhoids Ointment and Sufu(P>0.05). Musk Hemorrhoids Ointment was the most effective among the three in relieving the pain caused by phlebitis(P<0.05). There were no difference between Sufu and Hirudoid(P>0.05). Conclusion Musk Hemorrhoids Ointment can effectively prevent peripheral chemotherapeutic phlebitis caused by continuous infusion of 5⁃fluorouracil with affordable expense which is worthy of promotion in clinic use.%目的：探讨3种外用药物预防5⁃氟尿嘧啶持续泵入所致外周化疗性静脉炎的临床效果。方法将90例行5⁃氟尿嘧啶持续泵入化疗的食管鳞癌患者随机分为喜疗妥组、苏肤组和马应龙组，每组30例，3组患者均在连接完注射泵进行5⁃氟尿嘧啶化疗的同时沿穿刺静脉走向涂抹相应的药物，每日3次，每次间隔6 h，连续5 d。观察并记录3组患者化疗性静脉炎的发生情况。结果马应龙麝香痔疮膏和苏肤在降低静脉炎发生率、减轻静脉损伤程度方面的效果要优于喜疗妥（P<0.05），马应龙麝香痔疮膏和苏肤间则无差别（P>0.05）；马应龙麝香痔疮膏在缓解静脉炎所致疼痛方面的效果要优于苏肤和喜疗妥（P<0.05），苏肤和喜疗妥间则无差别（P>0.05）。结论马应龙麝香痔疮膏可有效预防5⁃氟尿嘧啶持续泵入所致外周化疗性静脉炎，且经济实惠，值得临床推广。