马来酸氟吡汀对带状疱疹后三叉神经痛常规治疗的影响

摘要

目的 探讨马来酸氟吡汀对带状疱疹后三叉神经痛常规治疗的影响.方法 选取2015年12月至2016年12月期间在本院疼痛门诊就诊的带状疱疹后三叉神经痛患者40例,随机分为观察组与对照组,每组20例.所有入组患者对本研究均知情并签署知情同意书.对照组患者给予口服加巴喷丁和氨酚羟考酮治疗,观察组患者给予口服加巴喷丁、氨酚羟考酮和马来酸氟吡汀治疗.比较2组患者治疗前后视觉模拟评分(VAS)、SF-36量表评分变化情况及临床治疗有效率.结果 治疗前2组患者VAS评分及SF-36量表各维度因子评分比较差异均无统计学意义(均P＞0.05);治疗后2组患者VAS评分与治疗前比较均显著下降(P＜0.05),观察组的VAS评分显著低于对照组(P＜0.05);治疗后2组患者SF-36量表各维度因子评分与治疗前比较显著升高(P＜0.05),观察组SF-36评分均显著高于对照组(P＜0.05);观察组患者临床治疗有效率高于对照组(P＜0.05).结论 在常规药物治疗基础上加用马来酸氟吡汀,能够有效提高带状疱疹后三叉神经痛的治疗效果,更好地缓解疼痛,提高患者生活质量.%Objective To investigate the treatment effect of flupirtine maleate on postherpetic trigeminal neuralgia and the subsequent effects on patient quality of life.Methods Forty patients with postherpetic trigeminal neuralgia were selected at our hospital from December 2015 to December 2016,and they were randomized and divided into a control group and an observation group.Patients in the control group were treated with gabapentin and oxycodone-acetaminophen,and the patients in the observation group were treated with flupirtine maleate on the basis of the control group.Visual analogue scale (VAS) scores,quality of life scores (SF-36 scale),and clinical effective rate were compared between the two groups before and after treatment.Results There was a significant decrease (P ＜ 0.05) in the VAS scores of the two groups after treatment when compared to those before treatment.The VAS score of the patients in the observation group was significantly lower than that of the patients in the control group (P ＜ 0.05).The scores for each dimension in the observation group were significantly higher than those in the control group (P ＜ 0.05).Conclusion When combined with the basic conventional treatment,flupirtine maleate can effectively improve the treatment effects in postherpetic trigeminal neuralgia and effectively relieve pain,thereby improving the quality of life.