Objective To analyze the effect of Longxuejie powder in combined with mesalazine tablets enema in the treatment of ulcerative colitis(UC). Methods A total of 70 patients with UC who were admitted in our hospital from August,2014 to August,2015 were included in the study and randomized into the observation group and the con-trol group. The patients in the two groups were given corresponding adjustment of acid-base imbalance and water and electrolyte disturbance,and the improvement of nutritional status. The patients in the control group were orally given mesalazine tablets(1. 0 g),four times a day. On this basis,the patients in the observation group were given Longxuejie powder(1. 0 g),dissolving in 150mL normal saline for enema,retaining in the intestinal tract for 1h,once a day. The patients in the two groups were given a continuous 4-week treatment. The levels of IL-8,IL-10,TNF-α,HCT,fibrino-gen,and whole blood viscosity before and after treatment in the two groups were observed,and the efficacy was evalua-ted. Results After treatment,the levels of IL-8 and TNF-α were significantly reduced,while the IL-10 level was sig-nificantly elevated,moreover,the degree in the observation group was significantly superior to that in the control group (P ﹤ 0. 05). The decreased degree of the levels of HCT,fibrinogen,and whole blood viscosity after treatment in the observation group was significantly superior to that in the control group(P ﹤ 0. 05). The total effective rate in the ob-servation group(91. 4℅ )was significantly higher than that in the control group(71. 4℅ )(P ﹤ 0. 05). Conclusion Longxuejie powder in combined with mesalazine tablets enema in the treatment of UC can significantly reduce the in-flammatory reaction,improve the hypercoagulable state,enhance the therapeutic effect,and improve the patients’liv-ing qualities.Objective To analyze the effect of Longxuejie powder in combined with mesalazine tablets enema in the treatment of ulcerative colitis(UC). Methods A total of 70 patients with UC who were admitted in our hospital from August,2014 to August,2015 were included in the study and randomized into the observation group and the con-trol group. The patients in the two groups were given corresponding adjustment of acid-base imbalance and water and electrolyte disturbance,and the improvement of nutritional status. The patients in the control group were orally given mesalazine tablets(1. 0 g),four times a day. On this basis,the patients in the observation group were given Longxuejie powder(1. 0 g),dissolving in 150mL normal saline for enema,retaining in the intestinal tract for 1h,once a day. The patients in the two groups were given a continuous 4-week treatment. The levels of IL-8,IL-10,TNF-α,HCT,fibrino-gen,and whole blood viscosity before and after treatment in the two groups were observed,and the efficacy was evalua-ted. Results After treatment,the levels of IL-8 and TNF-α were significantly reduced,while the IL-10 level was sig-nificantly elevated,moreover,the degree in the observation group was significantly superior to that in the control group (P ﹤ 0. 05). The decreased degree of the levels of HCT,fibrinogen,and whole blood viscosity after treatment in the observation group was significantly superior to that in the control group(P ﹤ 0. 05). The total effective rate in the ob-servation group(91. 4℅ )was significantly higher than that in the control group(71. 4℅ )(P ﹤ 0. 05). Conclusion Longxuejie powder in combined with mesalazine tablets enema in the treatment of UC can significantly reduce the in-flammatory reaction,improve the hypercoagulable state,enhance the therapeutic effect,and improve the patients’liv-ing qualities.%目的：观察美沙拉嗪缓释片联合龙血竭散灌肠对溃疡性结肠炎（UC）的疗效。方法收集70例 UC患者，随机分为观察组和对照组，各35例，2组均给予相应调节酸碱失衡、水电解质紊乱及改善营养状况等治疗。对照组以美沙拉嗪缓释片1.0 g 口服，4次/ d，观察组在对照组基础上给予龙血竭散1.0 g 溶于生理盐水150 mL 进行灌肠，肠道保留1 h，1次/ d，均连续治疗4周。观察治疗前后 IL-8、IL-10、TNF-α、红细胞压积、纤维蛋白原、全血黏度水平，并进行疗效评价。结果治疗后 IL-8、TNF-α明显降低，IL-10明显升高，且观察组优于对照组（P ﹤0.05）；治疗后红细胞压积、纤维蛋白原、全血黏度水平观察组降低程度优于对照组（P ﹤0.05）；观察组总有效率91.4℅，对照组71.4℅（P ﹤0.05）。结论美沙拉嗪口服联合龙血竭散灌肠可以明显减轻 UC患者炎性反应，改善血液高凝状态，提高治疗效果，改善患者生活质量。
展开▼
