It is a difficult to carry biological tissue regeneration and functional reconstruction for oral and maxillofacial deformities,especially for dental tissue defects. This project was designed to regenerate tooth , repair the defects of facial bones and reconstruct the function of salivary glands that providing the support for oral cavity. By using gene transfer and salivary gland endoscopy, the new techniques were developed for diagnosis and treatment of obstructive salivary gland diseases and for recovery of irradiation-induced salivary gland dysfunction. We proposed a new concept called as “biological roots” by using of stem cells and tissue engineering technology, the biological roots with mastication function was successfully regenerated in the swine; based on tooth development strategy, new ways for whole tooth regeneration were established and the new seed cells was discovered. Key technologies, parameters and new devices were obtained for development of jaw osteodistraction to improve the complex maxillofacial defects effectively by endogenous jaw bone regeneration. This research and its application in clinic improved tissue regeneration and restoration of oral and maxillofacial tissue,normalized the diagnosis and treatment, and promoted the development of oral and maxillofacial surgery and translational medicine.%针对以牙齿为中心的口腔颌面组织缺损畸形缺乏生理性修复及功能重建困难的问题,"口腔颌面组织修复及功能重建技术的研究及应用"项目组,围绕牙齿,颌面骨及提供口腔支撑环境分泌唾液的涎腺进行了较系统、全面的专题研究.利用涎腺内镜及基因转导技术诊治阻塞性涎腺疾病,恢复涎腺功能,重建放射损伤涎腺功能.提出"生物牙根"理念,利用干细胞与组织工程技术,成功再生了具有咀嚼功能的生物牙根;基于牙发育提出牙再生新方式并发现种子细胞.确立颌骨牵张成骨关键技术及参数,通过数字测量技术提高颌面创伤的整复效果,研发专用牵引装置及关键技术进行颌骨内源性骨再生.该项目的 研究及应用,提高了我国口腔颌面组织再生修复的诊治水平,推动口腔医学领域及转化医学的发展.
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