目的 评价使用浓缩生长因子(concentrate growth factors,CGF)联合Bio-oss骨粉在上颌前牙区进行拔牙位点保存的临床效果.方法 选取需要拔除上颌前牙的病人26例共32颗牙,根据性别分层,采用数字表法随机分为2组,试验组(CGF组,16颗)拔牙窝内植入CGF和Bio-oss骨粉混合物,CGF膜关闭拔牙窝;对照组(自然愈合组,16颗)拔牙窝搔刮后放置止血海绵,待其自然愈合.病人于术后6个月时复诊,拍摄锥形束计算机断层扫描(cone beam computed tomography,CBCT),分别与术前CBCT比较,观察并测量拔牙位点牙槽骨高度和宽度的变化.结果 在CGF组,唇、腭侧骨板高度术后6个月和术前相比,差异无统计学意义(P＞0.05),牙槽嵴宽度术后6个月和术前相比,差异有统计学意义(P＜0.05);在对照组,唇、腭侧骨板高度和牙槽嵴宽度术后6个月和术前相比,差异均具有统计学意义(P＜0.05);2组间比较,唇、腭侧骨板高度和牙槽嵴宽度的变化差异有统计学意义(P＜0.05).结论 CGF联合Bio-oss骨粉进行拔牙位点保存可以有效地维持牙槽嵴的宽度和高度,为种植修复创造有利条件.%Objective To evaluate the clinical effect of site preservation by using concentrate growth factors (CGF) combined with Bio-oss bone powder in maxillary anterior region.Methods Thirty-two maxillary anterior teeth of 26 patients that should be extracted were randomly divided into two groups.For CGF group (16 cases),CGF combined with Bio-oss was implanted into teeth extraction socket,then covered the socket with CGF membrane;for control group(16 cases),teeth extraction socket was placed with hemostatic sponge after scoraping.Cone beam computed tomography (CBCT) should be taken after 6 months,then compared with preoperative,observed and measured the change of width and height of the alveolar bone at extraction site.Results In CGF group,the heights of labial and palatal bone plates between 6 months after surgery and preoperative were no statistically significant (P ＞ 0.05),and the widths between 6 months after surgery and preoperative were statistically significant (P ＜ 0.05).In control group,the heights of labial and palatal bone plates and the widths between 6 months after surgery and preoperative were statistically significant (P ＜ 0.05).The differences of changes between the two groups were statistically significant (P ＜ 0.05).Conclusion CGF combined with Bio-oss being used for preservation of teeth extraction site,which may effectively keep the width and height of alveolar ridge,it is favorable for implanting and repairing.
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