Objective To investigate the efficacy and safety of intravenous thrombolysis of urokinase combined with aspirin and clopidogrel in the treatment of early cerebral infarction in the elderly. Method 112 patients with early-stage cerebral infarction treated in our hospital from January 2015 to February 2018 were randomly divided into two groups according to the random number table method, 56 cases in each group. In the control group, intravenous thrombolysis with urokinase and oral aspirin were used. The observation group was combined with clopidogrel antiplatelet therapy. The clinical efficacy, safety and hemodynamic parameters before and after treatment were compared between the two groups. Results The clinical efficacy of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group had no significant differences compared with the control group (P>0.05); the hematocrit, blood specific viscosity, plasma specific viscosity and fibrinogen of the observation group after treatment were all lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The combined treatment of intravenous thrombolysis of urokinase with aspirin and clopidogrel in the trerapy of early cerebral infarction in the elderly can effectively improve the clinical effect and hemodynamic index, and has a certain safety. It is worth applying in clinic.%目的 探讨尿激酶静脉溶栓与阿司匹林、氯吡格雷联合治疗老年早期脑梗死的疗效及安全性.方法 选取本院2015年1月至2018年2月收治的老年早期脑梗死患者112例,按随机数字表法分为2组,各56例.对照组采用尿激酶静脉溶栓及口服阿司匹林治疗,观察组在此基础上联合氯吡格雷抗血小板治疗.对比两组临床疗效、安全性及治疗前后血流动力学指标.结果 观察组临床疗效高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率与对照组相比无明显差异(P>0.05);观察组治疗后红细胞比容、全血比黏度、血浆比黏度、纤维蛋白原均低于对照组,差异有统计学意义(P<0.05).结论 尿激酶静脉溶栓与阿司匹林、氯吡格雷联合治疗老年早期脑梗死可有效提高临床疗效,改善血流动力学指标,且具备一定安全性,有临床应用价值.
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