绝经前单侧卵巢切除后老年女性认知功能的改变

摘要

Objective Clinical studies about the impact of estrogen on cognitive function in women were inconsistent.Our study examined differences of cognitive function among older women with unilateral oophorectomy before menopause and those with natural menopasue.Methods We performed a hospital-based, case-control study of 50 older women with unilateral oophorectomy before menopause and 50 cases matched control women.All the participants were administered neuropsychological assessments and the cognitive test scores were compared between the two groups.Results Surgically menopausal women performed worse than ageand education-matched control subjects on selected cognitive tests of word learning and delay recall( P ＜ 0.05 ).Conclusion There are some cognitive function impairment in the older women with unilateral oophorectomy before menopause.This result suggests that unilateral oophorectomy before menopause may have a long-term adverse effect on cognitive function in older women.%目的 本研究观察绝经前单侧卵巢切除伴有或无子宫切除的老年人认知功能的改变,探讨单侧卵巢切除对认知功能的远期影响.方法 采用1:1年龄及教育配比病例对照研究,选取绝经前行单侧卵巢切除及自然绝经的老年女性各50名,对其认知功能进行测定并比较两组的差异.结果 绝经前单侧卵巢切除老年女性的词语学习记忆及延迟回忆分数均较对照组降低(P＜0.05).结论 绝经前单侧卵巢切除可能对女性认知功能产生远期损害.