Objective: Research on enhancing early osseointegration of cementless implants to improve early fixation and reducing of risk of loosening. Methods: Thirty New Zealand rabbits were divided into two groups at random. BMP combined with DBM 30 mg was inserted around the prosthesis in 15 rabbits as experimental group, the remaining rabbits were served as control group. After 4, 8, and 12 weeks, five rabbits were sacrificed in each group. The humerus with the implants were retrieved. Bone ingrowth was analyzed by none-decalcification bone ground section and biomechanical test. Results: At the end of 4 and 8 weeks the osseointegration rates of BMP group were higher than those of control(P 0.05). Conclusion: BMP combination can enhance bone growth into gaps around cementless implants, especially in the early postoperative period.
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