Circulating thrombospondin-2 in patients with moderate-to-severe chronic heart failure due to coronary artery disease

摘要

Chronic heart failure(CHF)remains a leading cause of morbidity and mortality.In the current study,we aimed to evaluate the predictive value of circulating fhrombospondin-2(TSP-2)for cumulative survival in patients with ischemic CHF due to coronary artery disease(CAD).The results showed that during a median follow-up of2.18 years,21 participants died and 106 subjects were hospitalized repeatedly.The median circulating levels of TSP-2 in patients who survived and those who died were 0.63 ng/mL(95%CI=0.55-0.64 ng/mL)and 1.03 ng/mL(95%CI=0.97-1.07 ng/mL)(P<0.001).Circulating TSP-2 independently predicted all-cause mortality(OR=1.27;95%CI=1.08-1.59;P=0.002),CHF-related death(OR=1.16;95%CI=1.02-1.50;P<0.001),and also CHF-related rehospitalization(OR=1.12;95%CI=1.07-1.25;P<0.001).In conclusion,among CAD patients with symptomatic CHF,increased circulating TSP-2 is correlated with increased 3-year CHF-related death,all-cause mortality,and risk for recurrent hospitalization.