PCSK9 and triglyceride-rich lipoprotein metabolism

摘要

Pro-protein convertase subtilisin-kexin 9(PCSK9) is known to affect low-density lipoprotein(LDL) metabolism,but there are indications from several lines of research that it may also influence the metabolism of other lipoproteins,especially triglyceride-rich lipoproteins(TRL).This review summarizes the current data on this possible role of PCSK9.A link between PCSK9 and TRL has been suggested through the demonstration of(1) a correlation between plasma PCSK9 and triglyceride(TG) levels in health and disease,(2) a correlation between plasma PCSK9 and markers of carbohydrate metabolism,which is closely related to TG metabolism,(3) an effect of TG-lowering fibrate therapy on plasma PCSK9 levels,(4) an effect of PCSK9 on postprandial lipemia,(5) an effect of PCSK9 on adipose tissue biology,(6) an effect of PCSK9 on apolipoprotein B production from the liver and intestines,(7) an effect of PCSK9 on receptors other than low density lipoprotein receptor(LDLR) that are involved in TRL metabolism,and(8) an effect of anti-PCSK9 therapy on serum TG levels.The underlying mechanisms are unclear but starting to emerge.