Manifestations of type 2 diabetes in corneal endothelial cell density,corneal thickness and intraocular pressure

摘要

We sought to evaluate central corneal thickness(CCT),corneal endothelial cell density(ECD)and intraocular pressure(IOP)in patients with type 2 diabetes mellitus(DM)and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized study.We measured ECD,CCT and IOP of125 patients with type 2 DM(mean age 57.1±11.5 years)and compared them with 90 age-matched controls.Measured parameters were analyzed for association with diabetes duration and glucose control modalities(insulin injection or oral medication)while controlling for age.In the diabetic group,the mean ECD(2511±252 cells/mm^2),mean CCT(539.7±33.6μm)and mean IOP(18.3±2.5 mmHg)varied significantly from those the control group[ECD:2713±132 cells/mm^2(P10 years when compared with those with duration of10 years than those with duration of0.05).None of the measured parameters was significantly associated with diabetes duration and treatment modality(P>0.05).In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.