Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases,the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated.SpragueDawley rats were fed a diet containing the oils or trans-fat,and then body weights,blood lipids,and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion(MCAO) were analyzed.All the oils and trans-fat,except perilla oil,significantly increased body fats and body weight gain.Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides,respectively,while perilla oil decreased both cholesterols and triglycerides.Perilla oil not only attenuated cerebral infarction,but also restored locomotor activity and rota-rod performances of MCAO rats.It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke.
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