抗凝药物在脊柱骨折手术术前应用的效果

摘要

Objective:To investigate the effect of preoperative application of anticoagulant drugs on spinal fracture. Methods:160 cases of pa-tients undergoing spinal fracture surgery were selected and randomly divided into observation group and control group, 80 cases in each group. The pa-tients in observation group accepted 10mg/d rivaroxaban until 12 h pre-operation, and those in control group did not adopt any anticoagulant drugs. After operation, all patients accepted rivaroxaban for one month, and the clinic effects between the two groups were compared. Results:There were no significant differences of operative time and venous thrombus embolism (VTE) incidence between the two groups ( P >0. 05);The intraoperative blood loss and postoperative drainage volume of patients undergoing internal fixation of fracture in observation group was higher than those in control group ( P <0. 05). Conclusions:Preoperative application of rivaroxaban to patients undergoing spinal fracture surgery can increase the risk of sur-gery with mounting intraoperative blood loss and postoperative drainage volume, but cannot reduce the incidence of VTE. It is unnecessary to use pre-operative anticoagulant drugs treatment for spinal fracture surgery.%目的：：探讨抗凝药物在脊柱骨折手术术前应用的效果。方法：将行脊柱骨折手术患者160例作为研究对象,随机分为观察组和对照组各80例,观察组患者在入院后口服10 mg/d利伐沙班抗凝剂直至术前12 h停止给药,对照组患者不服用抗凝药物,两组患者在术后服用利伐沙班1个月,观察两组患者的临床疗效。结果：两组患者手术时间和深静脉血栓栓塞(venous thrombus embolism,VTE)发生率比较差异无统计学意义( P >0.05),观察组行加压骨折内固定术的患者术中出血量和术后引流量高于对照组( P <0.05)。结论：脊柱骨折患者术前使用利伐沙班抗凝药物会增加术中出血量和术后引流量,增加手术的风险,但不降低VTE的发生率,因此脊柱骨折患者术前使用抗凝药物没有必要。