听神经病谱系障碍患者时域间隔感知能力的研究

摘要

Objective This study was aimed at investigating the ability of temporal gap detection (TGD) in listeners with auditory neuropathy spectrum disorder (ANSD ) .Methods The temporal gap detection thresholds were measured for subjects using a TGD program developed by University of California ,Irvine .Three groups of subjects were recruited in this study ,including 12 subjects with normal hearing ,12 subjects with sensorineural hearing loss (SNHL) ,and 15 subjects with ANSD .The differences of TGD thresholds among the three groups of subjects were analyzed using a one - sample ANOVA method .Results No significant difference of the TGD thresh‐old was observed between two ears for all the subjects .The mean and standard deviation of the gap - detection threshold for both ears was about 3 .9 ± 1 .1 ms ,3 .6 ± 1 .1 ms ,and 13 .7 ± 9 .9 ms for normal - hearing subjects , subjects with SNHL ,and subjects with ANSD ,respectively .The TGD threshold in subjects with ANSD was sig‐nificantly higher than those of in normal hearing group (P< 0 .01) and SNHL group (P< 0 .01) ,while no signifi‐cant difference was found in TGD thresholds between normal - hearing subjects and subjects with SNHL .Conclusion For listeners with auditory neuropathy spectrum disorder ,their ability to resolve temporal information was de‐graded with a large individual variability .%目的：探讨听神经病谱系障碍患者的时域间隔感知能力。方法使用美国加州大学尔湾分校开发的时域间隔感知能力测试软件，分别测试成年听力正常者（12例）、感音神经性听力损失者（12例）和听神经病谱系障碍者（15例）能够分辨出刺激声中无声间隔的最小时长，即时域间隔感知（temporal gap dection ，TGD）阈值，比较三组受试者 TGD 的差异。结果三组受试者左右耳间 TGD 阈值差异均无统计学意义（P＞0．05）；听力正常组、感音神经性听力损失组和听神经病谱系障碍组双耳平均 TGD 阈值分别为3．97±1．12、3．62±1．14、13．72±9．89 ms ，感音神经性听力损失组 TGD 阈值与听力正常组差异无统计学意义（P ＞0．05），而听神经病谱系障碍组 TGD阈值显著高于听力正常组和感音神经性听力损失组（P＜0．01）。结论听神经病谱系障碍患者听觉系统的时域间隔感知能力下降，且个体差异较大。