冠心平对冠心病心绞痛患者血管内皮功能障碍的调节作用

摘要

Objective To investigate the effect of the compound preparation Guanxinping in improving vascular endothelial function in patients with angina pectoris.Methods A total of 80 patients with angina pectoris were randomly divided into experimental group and control group, with 40 patients in each group.The patients in the experimental group were given Guanxinping in addition to routine drug treatment, and those in the control group were given Xinkeshu in addition to routine drug treatment.The course of treatment was 4 weeks for both groups.The clinical outcome was observed in both groups, and the serum levels of nitric oxide (NO), endothelin-1 (ET-1), thromboxane B2 (TXB2), and 6-ketone prostaglandin F1 alpha (6-keto-PGF1α) were compared before treatment and after 4 weeks of treatment.Results There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05).After treatment, the experimental group had significant increases in NO and 6-keto-PGF1α and significant reductions in ET-1 and TXB2 (P<0.05);the control group also had significant increases in NO and 6-keto-PGF1α (P<0.05) and reductions in ET-1 and TXB2 (P>0.05).The experimental group had significantly better improvements in these indices compared with the control group (P<0.05).Conclusion Guanxinping can act on vascular endothelial function through various targets, which may be one of its mechanisms of action in the prevention and treatment of coronary heart disease.%目的 观察复方制剂冠心平改善冠心病心绞痛患者血管内皮功能的效果.方法 将80例冠心病心绞痛患者按照随机平行分组方法分为试验组40例、对照组40例,试验组在常规药物治疗的基础上服用冠心平片,对照组在常规药物治疗基础上服用心可舒片,两组均治疗4周.观察两组临床疗效,比较治疗前及治疗4周后患者血清一氧化氮(nitric oxide,NO)、内皮素-1(endothelin-1,ET-1)、血栓素B2(thromboxane B2,TXB2)、6-酮前列腺素F1α(6-ketone prostaglandin F1 alpha,6-keto-PGF1α)水平.结果 两组患者临床疗效分布比较,差异具有统计学意义(P<0.05).试验组治疗后NO、6-keto-PGF1α较治疗前显著升高(P<0.05),ET-1、TXB2较治疗前显著降低(P<0.05);对照组NO、6-keto-PGF1α较治疗前显著升高(P<0.05),ET-1、TXB2较治疗前有降低趋势,但差异无统计学意义(P>0.05).与对照组比较,试验组各项指标改善更明显,差异具有统计学意义(P<0.05).结论 冠心平防治冠心病的作用机制之一,可能是通过多靶点作用于血管内皮功能而实现的.