Antiulcer activity of aqueous extract of leaves ofMadhuca indica J. F. Gmel against naproxen induced gastric mucosal injury in rats

摘要

Objective:To evaluate antiulcer potential of aqueous extract ofMadhuca indica(M. indica)J. F.Gmel leaves in rats.Methods:Aqueous extract of M. indicaJ.F.Gmel leaves was tested at the dose of100,200 and400 mg/kg, p.o. against naproxen(30 mg/kg, p.o) induced gastric ulcer. Omeprazole(30 mg kg, p.o.) was used as a positive standard.Ulcerated area was measured by ImageJ software.Various antioxidant parameter likeSOD,GSH,MDA,MPO,NO and histamine were also determined.Results:After4 week treatment period, desired aim was achieved using aqueous extract of plant ofM. indica at the dose of200 and400 mg/kg, p.o.(P<0.01, P<0.001) showed significant reduction in ulcerated area and ulcer index as compared to control group. Omeprazole(30 mg/kg, p.o.) was more effective in reducing ulcerated area after30 days treatment period.In addition,SOD,GSH,NO significantly increased;MDA,MPO content significantly lowered when compared with control group.Histamine content didn’t show any significant change at all the three doses.Conclusions:Our finding suggests that aqueous extract ofM. indicaJ.F. Gmel leaves is effective in gastric ulcer protection.