The acute effect of the antioxidant drug“U-74389G” on red blood cells levels during hypoxia reoxygenation injury in rats

摘要

Objective:To examine the effect of the antioxidant drug“U-74389G”, on rat model and particularly in a hypoxia reoxygenation(HR) protocol.The beneficial effect or non-effectiveness of that molecule was studied hematologically using mean red blood cells levels.Methods:40 rats of mean weight231.875 g were used in the study.Red blood cells levels were measured60 min after reoxygenation(groupsA andC) and120 min after reoxygenation(groupsB andD) with administration of the drugU-74389G only in groupsC andD.Results:U-74389G administration non-significantly increased the red blood cells level by(0.64±0.32)%(P=0.8106).Reoxygenation time also non-significantly increased the red blood cells level by(4.63±2.36)%(P=0.0680). However,U-74389G administration and reoxygenation time together non-significantly increased the red blood cells level by(1.05±0.53)%(P=0.4911). Conclusions:Results of this study show that U-74389G administration, reoxygenation time and their interaction non significantly increased the red blood cells levels within2 hours’ time interval.