Objective To explore the relationship between peripheral blood level of estrogen(E2) and Tamoxifen for ER+breast cancer. Methods 50 patients pathologically confirmed after surgery as ER+breast cancer were received endocrine therapy (as A group). including Premenopausal patients(A1)28 cases,22 cases of postmenopausal patients (A2);and there were 2 control groups. Serum E2 was detected before treatment. Results Before treatment,serum E2 level in group A was significantly lower than in group B and group C (P<0.05). Serum E2 levels before Tamoxifen treatment was lower than(P<0.05) after treatment in group A;Serum E2 in group B before and after surgery had no significant difference (P>0.05). After Tamoxifen treatment,7 cases of group A patients increased serum E2 levels, 6 cases in A1 group (21.43%),1 patient in A2 Group (4.54%),6 cases of E2 level in A1 was signifi-cantly higher than A2 (P<0.05). In group A,the total effective rate was 70.0%(35/50). Recent response rate (CR+PR) were 28.57%(2/7) and 76.74% (33/43 cases) in patients with elevated serum E2 and normal serum E2. Hc=3.021 and the difference was signifi-cant(P<0.05). 7 cases of elevated serum E2,the majority was invasive ductal carcinoma,and TNM stage was late and endocrine therapy was less effective(P<0.05). Conclusion Breast cancer patients with low estrogen levels after treatment are more effective, and patients with higher estrogen levels often fails the treatment.%目的：探讨外周血雌激素（E2）水平与三苯氧胺治疗ER+乳腺癌疗效关系。方法对我院收治的50例经病理证实的手术后ER+乳腺癌患者进行内分泌治疗（A组），其中绝经前患者（A1组）28例，绝经后患者（A2组）22例；同时设立对照组：良性乳腺疾病（B组）和健康体检（C组）各50例。治疗前、后进行血清E2检测。结果治疗前，A组血清E2水平明显低于B组、C组（P＜0.05）。 A组三苯氧胺治疗前血清E2水平低于治疗后（P＜0.05）；B组手术前血清E2与术后血清E2无显著性差异（P＞0.05）。三苯氧胺治疗后，A组患者血清E2水平升高的7例中，其中A1组6例（占21.43%），A2组1例（4.54%），A1组血清E2水平升高的例数及水平6例显著高于A2组（P＜0.05）。A组三苯氧胺治疗后总有效率70.0%（35/50）。血清E2升高与血清E2正常的患者近期有效率（CR+PR）分别为28.57%（2/7例）、76.74%（33/43例），两组比较Hc=3.021,差异有显著性（P＜0.05）。血清E2升高7例患者中，以浸润性导管癌乳腺癌居多，且TNM分期晚，内分泌治疗效果较差（P＜0.05）。结论三苯氧胺抑制后雌激素水平低的患者，治疗疗效好，相反在三苯氧胺治疗过程中，雌激素水平一直高居不下或者在治疗过程中出现雌激素水平最高者，往往治疗失败。
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