目的 研究糖基化终产物(AGEs)与血管细胞黏附分子1(VCAM-1)间的关系,探讨AGEs在动脉粥样硬化中的作用.方法 分别抽取30例健康人群(A组)、32例糖尿病患者(B组)及36例冠心病患者(C组)的外周血液,用ELISA法检测各组血清中AGEs与VCAM-1的水平.结果 B组AGEs和VCAM 1浓度均较A组明显升高[(12.43±0.52) U/ml vs.(8.82±0.36) U/ml和(735.50±55.75) pg/ml vs.(417.80±27.34) pg/ml](P＜0.01)；而C组AGEs和VCAM-1浓度为(9.04±0.38) U/ml和(417.80±27.34) pg/ml,均与A组相仿(P＞0.05).B组、C组血清中AGEs浓度与VCAM-1浓度均呈显著正相关(r=0.7347、0.6329,P＜0.01).结论 AGEs在体内可以促进VCAM-1的分泌,这可能是糖尿病患者易患动脉粥样硬化的重要机制之一.%Objective To investigate the correlation between advanced glycation end products (AGEs) and monocyte chemoattractant protein-1 (VCAM-1) and the effect of AGEs on atherosclerosis. Methods The peripheral blood was taken in 30 cases of healthy people(group A) ,32 cases of diabetes mellitus (DM, group B) and 36 cases of coronary heart disease (CHD, group C). Serum AGEs and VCAM-1 were detected by ELISA. Results The concentrations of AGEs and VCAM-1 in group B were higher than those in group A[(12. 43 0. 52) U/ml vs. (8. 82 ± 0. 36) U/ml and (735.50±55.75) pg/ml vs. (417.80 ± 27.34) pg/ml] (P<0. 01). Serum AGEs and VCAM-1 were (9. 04 ± 0. 38) U/ml and (498. 80±87. 17) pg/ml in grop C, which were not significant different from those in group A(P>0. 05). Serum level of AGEs was positively correlated with that of VCAM-1 in groups of B and C(r=0. 7347 and 0. 6329,P<0. 01). Conclusion AGEs can promote the secretion of VCAM-1 in vivo, which may be an underlying mechanism of atherosclerosis in DM patients.
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