甲状腺功能6项指标联合检测评估甲状腺疾病的价值

摘要

目的 探讨甲状腺功能6项指标联合检测评价甲状腺功能及其临床意义.方法 甲状腺疾病患者200例均分为四组:甲状腺功能亢进(A)组、Graves病(B)组、甲状腺功能减退(C)组和桥本甲状腺炎(D)组;另设健康对照组(E组,50例).采用免疫化学发光法检测血清游离三碘甲状腺氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺受体抗体(TRAb)水平,分析组间差异.结果 A组与B组血清FT3、FT4水平明显高于E组,TSH水平低于E组;C组与D组血清FT3、FT4水平明显低于E组,TSH水平高于E组(P＜0.05);五组FT3、FT4、TSH诊断符合率差异均无统计学意义(P＞0.05).A组、B组、C组、D组患者血清TGAb、TPOAb、TRAb阳性率与E组比较差异有统计学意义(P＜0.05).结论 联合检测FT3、FT4、TSH和TGAb、TPOAb和TRAb在甲状腺疾病的鉴别诊断、治疗及判断预后具有参考价值,可指导临床用药.%Objective To explore the clinical significance of combined detection of 6 indexes for evaluation of thyroid function.Methods A total of 200 patients with thyroide disesases was equally divided into four groups of A (with hyperthyroidism),B (with Graves' disease),C (with hypothyroidism),D(with Hashimoto's thyroditis).Fifty healthy people(group E) were taken as the controls.Serum levels of free triiodothyronine (FT3),free thyroxine (FT4),thyroid stimulating hormone (TSH),thyroglobulin antibody (TGAb),thyroid peroxidase antibody (TPOAb) and thyrotrophin receptor antibody(TRAb) were detected by chemiluminescence imrnunoassay and the differences among 5 groups were analyzed.Results Serum FT3 and FT4 were higher,but TSH was lower,in groups of A and B than those in group E(P＜0.05).Serum FT3 and FT4 were lower,but TSH was higher,in groups of C and D than those in group E(P＜0.05).The accordance rates of FT3,FT4 and TSH in the diagnosis of 4 kinds of thyroide disesases were similar(P＞0.05).The positive rates of TGAb,TPOAb and TRAb were statistically different between the groups of A,B,C,D and the group E(P＜0.05).Conclusion Combined detection of FT3,FT4,TSH,TGAb,TPOAb and TRAb plays an important role in identification,diagnosis and treatment of thyroid diseases.