高血压前期患者血清尿酸(uA)水平的变化及其与颈动脉粥样硬化的病变关系

摘要

目的 观察高血压前期患者血清尿酸(uA)水平的变化及其与颈动脉粥样硬化的病变关系,总结其临床应用价值.方法 选取我院2010年8月至2011年12月收治的高血压前期患者56例,设为观察组A；选取同期原发性高血压患者68例,设为观察组B:再选取同期血压正常的人70例,设为对照组.观察、比较三组血清中的uA水平、血脂水平、颈总动脉内膜中层厚度(IMT)及其相关性.结果 观察组A、B血清中的uA水平、低密度脂蛋白(LDL-C)、IMT与对照组比较,差异有统计学意义(P＜0.05)；观察组A、B间的IMT比较,差异有统计学意义(P＜0.05)；观察组A患者血清中的uA水平、IMT与患者的血压呈现出明显的正相关关系( r=0.47、0.46,P＜0.05)；血清中的uA水平与IMT也呈现出明显的正相关关系(r=0.51,P＜ 0.05).结论 高血压前期患者血清尿酸水平升高,颈总动脉内膜中层厚度也同步增高,并会随着uA的不断升高,发展为动脉粥样硬化的危险性也增高；因此,临床上应重视对高血压前期患者进行筛查及早期防治,这对减少动脉粥样硬化的发生具有重要的临床意义.%Objective To explore changes in serum uric acid ( UA ) level and its association with carotid atherosclerotic lesions in patients with prehypertension.Methods 56 patients with prehypertension were assigned to study group A,68 patients with essential hypertension were assigned to study group B,and 70 normotensive people were enrolled into control group.Serum levels of UA and lipids and carotid artery intima-media thickness ( IMT ) and their correlation were observed and compared among the three groups.Results IMT and Ievels of UA and LDL-C differed significantly between the control group and the study groups A and B ( P＜ 0.05 ); there was a significant difference in IMT between group A and group B ( P＜ 0.05 ).In study group A,UA level and IMT were positively associated with blood pressure ( r=-0.47,0.46,P ＜ 0.05 ); and UA level was positively related with IMT ( r=0.51,P ＜ 0.05 ).Conclusions Serum uric acid level and carotid artery intima-media thickness increase in patients with prehypertension; and the risk of developing atherosclerosis is elevated with an increase in uric acid.Therefore,attention should be paid to the screening and early prevention of prehypertension to reduce the occurrence of atherosclerosis,which has important clinical significance.