联合检测缺血修饰白蛋白与心脏型脂肪酸结合蛋白在急诊心源性胸痛早期诊断中的价值

摘要

目的 评价联合检测缺血修饰白蛋白(IMA)与心脏型脂肪酸结合蛋白(H-FABP)在急诊心源性胸痛(CCP)早期诊断中的临床意义.方法 选取2013年1月至2014年1月我院收治的急诊胸痛＜3h的患者106例,检测IMA、H-FABP、心肌肌钙蛋白抗体(cTn1)、肌酸激酶同工酶(CK-MB)和心电图.结果 最后97例确诊为心源性胸痛,其中,IMA或H-FABP阳性81例(83.5％),cTn1阳性62例(63.9％),CK-MB阳性52例(53.6％),心电图阳性43例(44.3％),IMA联合H-FABP检测与cTn1、CK-MB、心电图检测阳性率比较差异有统计学意义(P＜0.05).结论 联合检测IMA与H-FABP在急诊心源性胸痛早期诊断中阳性检出率高,敏感度高,值得临床推广应用.%Objective To evaluate the clinical significance of the combined detection of ischemiamodified albumin (IMA) and heart-type fatty acid binding protein (H-FABP) in the early diagnosis of cardiac chest pain (CCP) at emergency room.Methods 106 patients diagnosed with chest pain less than 3 hours at the emergency room of our hospital from January,2013 to January,2014 were selcted as study objects,and then their IMA,H-FABP,cardiac troponin antibody (cTn1),and creatine kinase (CK-MB) were tested and they were checked with ECG.Results 97 patients were diagnosed with cardiac chest pain; among which,81 (83.5％) were positive in IMA or H-FABP,62 (63.9％) cTn1,52 (53.6％) CK-MB,and 43 (44.3％) ECG.There were statistical differences in test positive rate between IMA and H-FABP combined detection and cTn1,CK-MB,and ECG (P ＜ 0.05).Conclusions Combined detection of IMA and H-FABP in the early diagnosis of cardiac chest pain at emergency room has high detection rate and high sensitivity and deserves to be clinically generalized.