高压氧治疗急性脑梗死的疗效分析及对相关血清蛋白表达的影响

摘要

目的 探讨高压氧辅助治疗对急性脑梗死患者神经功能缺损及血清相关蛋白表达的影响.方法 选取本院神经内科2014年1月至2016年1月收治的急性脑梗死患者120例,随机分为常规方案治疗组(对照组)60例与高压氧治疗组(观察组)60例.比较两组治疗前后可溶性细胞间黏附分子-1(ICAM-1)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)及美国国立卫生研究院卒中量表(NIHSS)评分的变化,并评定治疗后临床疗效.结果 治疗15 d后,观察组患者基本痊愈10例,症状改善32例,无改变12例,恶化6例,总有效率为70.0％;对照组患者基本痊愈8例,症状改善23例,无改变21例,恶化8例,总有效率为51.6％;观察组疗效优于对照组(P＜0.05).两组患者治疗前血清ICAM-1、TNF-α、IL-6、MMP-9及NIHSS评分比较差异无统计学意义(P＞0.05),治疗15 d后上述指标均明显下降,且观察组下降幅度更为显著(P＜0.05).结论 急性脑梗死患者辅助高压氧治疗能够降低细胞炎症因子的水平,促进神经功能的恢复,改善患者预后,值得临床推广.%Objective To investigate the influence of adjunctive therapy of hyperbaric oxygen on neurological impairment and associated serum protein expression in patients with acute cerebral infarction.Methods 120 patients with cerebral infarction in department of neurology of our hospital from January 2014 to January 2016 were selected and randomly divided into the conventional treatment project group (control group,60 cases) and hyperbaric oxygen therapy group (observation group,60 cases).The changes of ICAM-1,TNF-α,IL-6,MMP-9,and NIHSS score were compared between the two groups.Results After 15 days of treatment,10 cases were cured in the observation group,the symptoms were improved in 32 cases,the symptoms did not significantly change in 12 cases,the symptoms worsened in 6 cases,and the total effective rate was 70.0％;while in the control group,8 cases were cured,the symptoms were improved in 23 cases,the symptoms did not significantly change in 21 cases,the symptoms worsened in 8 cases,and the total effective rate was 51.6％;the therapeutic effect in the observation group was significantly better than that in the control group (P＜0.05).There were no statistically significant differences in ICAM-1,TNF-α,IL-6,MMP-9,and NIHSS score between the two groups before the treatment (P＞0.05);after 15 days of treatment,the above indexes decreased significantly,and the decrease ranges of observation group were more significant (P＜0.05).Conclusion Adjunctive therapy of hyperbaric oxygen is effective in the treatment of acute cerebral infarction,which can improve prognosis and reduce the levels of inflammatory factors,worthy of clinical application.