腰大池引流联合万古霉素治疗开颅术后颅内感染的临床效果

摘要

Objective To investigate the clinical effect of lumbar drainage combined with vancomycin in the treatment of intracranial infection after craniotomy.Methods From January,2014 to January,2017,86 patients with intracranial infection after craniotomy were admitted into our hospital.All the patients were divided into an observation group and a control group using random number table method,43 for each group.The observation group were treated with lumbar cistern drainage combined with vancomycin,and the control group with vancomycin.The clinical efficacy,cerebrospinal fluid (CSF,) and incidence of adverse reactions were compared between the two groups.Results The effective rate was higher and the incidence of adverse reactions was lower in the observation group than in the control group (93.02％ vs.76.74％ and 9.30％ vs.27.91％),with a statistical difference (both P ＜ 0.05).The protein quantification,WBC,and intracranial pressure were significantly lower and the glucose level was higher after than before the treatment in both group,and all the above indicators were better in the observation group than in the control group after the treatment,with statistical differences (all P ＜ 0.05).Conclusions Lumbar cistern drainage combined with vancomycin for patients with intracranial infection after craniotomy is significantly effective,and can improve the clinical symptoms and decrease the incidence of adverse reactions.%目的 探究腰大池引流联合万古霉素治疗开颅术后颅内感染的临床效果.方法 选择2014年1月至2017年1月本院收治的开颅术后颅内感染患者86例,根据随机数字表法将所有患者分为观察组和对照组,各43例.观察组腰大池引流联合万古霉素治疗,对照组万古霉素治疗,比较两组临床疗效、脑脊液指标、不良反应发生率.结果 观察组治疗有效率高于对照组(93.02％比76.74％),不良反应发生率低于对照组(9.30％比27.91％),差异具有统计学意义(均P＜0.05);与治疗前相比,两组治疗后蛋白定量、WBC、颅内压均明显降低,葡萄糖水平明显提高,差异具有统计学意义(均P＜0.05);治疗后,观察组蛋白定量、WBC、颅内压及葡萄糖水平改善情况优于对照组,差异具有统计学意义(均P＜ 0.05).结论 腰大池引流联合万古霉素治疗开颅术后颅内感染患者临床疗效较为显著,可改善患者临床症状,不良反应发生率低.