Gastric cancer is one of the most common digestive cancers in clinic, with relatively high morbidity and mortality worldwide. Until now, the pathogenesis of gastric cancer is still unclear. The proposal of four new molecular subtypes for gastric cancer, namely microsatellite instability (MSI), Epstein-Barr virus (EBV), chromosomal instability (CIN) and genomically stable (GS), has supplemented the histopathological subtypes effectively. It not only shows the specific genome characteristics of gastric cancer, but also is of great guiding significance in clinical selection of effective targeted treatment and in grouping of patients with gastric cancer. Studies on epidemiology and molecular subtypes of gastric cancer can provide specific therapeutic protocols and advice for the treatment of this disease, which is of great clinical significance. This study mainly reviewed the advances in the epidemiological studies and the four molecular subtypes of gastric cancer, aiming to provide reference for the treatment of gastric cancer with different molecular subtypes.
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