Background: MiRNA?141 has been shown to play an important role in cancer formation and progression. However, the prognostic significance of miRNA?141 expression in human cancers remained contradictory. Thus, we carried out a meta?analysis of 26 relevant studies to investigate the prognostic value of miRNA?141 expression in multiple human malignancies. Methods: Eligible studies were searched in the online databases PubMed, Embase and Web of Science up to December 1st, 2017. Pooled hazard ratios (HRs) with 95％ confidence intervals (CIs) were calculated to investigate the association between high miRNA?141 and the prognosis of cancer. Results: In total, 26 eligible studies were included in this meta?analysis. Our results showed that high miRNA?141 expression was significantly associated with a poor overall survival (OS) (pooled HR = 1.51, 95％ CI: 1.10?2.09), but has no significant association with progression?free survival (PFS)/disease?free survival (DFS)/disease?specific survival (DSS) (pooled HR =1.04, 95％ CI: 0.82?1.34). Furthermore, in the term of OS, when stratified by ethnicity, increased miRNA?141 expression was significantly associated with unfavorable OS only in Asians (pooled HR = 1.58, 95％ CI: 1.01?2.49). Moreover, in the subgroup analysis by detected sample, the results were significant only in Blood subgroup (pooled HR = 2.37, 95％ CI: 1.18?4.75). Conclusions: Our results demonstrated high miRNA?141 expression was better at predicting patient survival rather than disease progression for malignant tumors, especially in Asians. Considering the relative insufficiency of studies, more studies and further investigations were needed in the future.
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