脑性瘫痪动物模型的研究进展

摘要

Cerebral palsy is a major cause of severe chronic disability in children. Experimental models aim to replicate one or more features of cerebral palsy in developing animals. These models are as heterogeneous as the disorder itself, such as timing.and mechanism of injury (stroke, infection, congenital malformation or asphyxia),target of injury (white matter or neurons) or function outcome. This review is to summarize different experimental models in cerebral palsy.%脑性瘫痪（脑瘫）是导致儿童严重慢性残疾的重要原因。应用动物模型的目的是在动物身上复制一种或更多的脑瘫特征来进行研究，而这些模型和疾患本身一样是具有异质性的，如损伤发作的时间和机制（中风、感染、先天畸形或窒息）、损伤的靶点（白质或神经元）或功能结果等。该文对不同的脑瘫动物模型作一综述。