高迁移率族蛋白B1与脓毒症的关系研究进展

摘要

高迁移率族蛋白B1(high mobility group box 1 protein,HMGB1)是存在于真核细胞内的非组蛋白染色体结合蛋白,其参与维持核小体结构和调整基因转录,研究发现HMGB1是炎症反应中潜在的促炎细胞因子.在机体感染时(尤其是脓毒症),HMGB1在血清和组织中的水平均升高,且越来越多的研究证实:HMGB1在脓毒症实验模型中是一个晚期的促炎细胞因子和潜在的治疗靶目标.该文主要概述了HMGB1的生物学功能及HMGB1抑制剂对炎症性疾病治疗的潜在作用.%High mobility groupbox 1 (HMGB1),a highly conserved protein previously known as a DNA-binding protein involved in maintenance of nucleosome structure and regulation of gene transcription,was recently found to act as a potent proinflammatory cytokine during infection responses.Levels of HMGB1 increase in serum and tissues during infection,especially in sepsis.A growing number of studies have demonstrated that HMGB1 is a cytokine that can mediate inflammation and is a potential therapeutic target in experimental models of sepsis.In this article,we will describe the biological function of HMGB 1 and HMGB 1 inhibitors for a potential role of inflammatory disease treatment.