消化道黏蛋白基因研究进展

摘要

消化道疾病的发病率逐年增加,但其病因及发病机制仍未完全阐明,如炎症性肠病、消化道肿瘤、过敏性疾病等.近年来黏蛋白( mucin,MUC)基因在消化道疾病的发生发展中的作用日益受到重视,MUC是消化道黏液主要成分,是形成消化道屏障主要因素,与胃肠道上皮、肠道微生物、炎症因子紧密相关.此外消化道MUC基因,尤其是MUC1、MUC2基因异常表达与消化道炎症、肿瘤有关.目前认为消化道MUC基因表达有助于消化道疾病发病机制、诊断治疗及预后判断的研究.%The incidence of gastrointestinal diseases increases every year.Etiology and pathogenesis of gastrointestinal diseases have been not yet elucidated,such as inflammatory bowel disease,gastrointestinal cancers,and allergic diseases.In recent years,the role of mucin genes expression in gastrointestinal diseases has been paying much attention to.Studies have shown that mucins are the main component of mucus in the digestive tract,and a major factor in the formation of the gastrointestinal barrier.Mucins are related to gastrointestinal epithelium,intestinal microflora and inflammatory factors.Abnormal expression of gastrointestinal mucin genes,especially MUC1 and MUC2,are related to Gastrointestinal inflammation and cancer.Currently gastrointestinal mucin genes expression contribute to exploring the diagnosis,treatment and prognosis of digestive diseases.This study is to summarize the progress in gastrointestinal mucin genes expression.