非编码RNAs在脓毒症肺损伤中的研究进展

摘要

非编码RNAs是指一类不具有编码蛋白质功能的RNA分子,主要包括微小RNAs、长链非编码RNAs和环状RNAs等.脓毒症指因宿主对感染的反应失调而导致的危及生命的器官功能障碍,肺脏损害首当其冲.近年来的研究发现,这些非编码RNAs,尤其是微小RNAs,可以在基因转录、RNA成熟和蛋白质翻译等多个水平调控基因的表达,进而引起机体促炎因子及炎症介质的释放和活化、血管内皮损伤等病理生理过程,最终导致脓毒症肺损伤的发生.研究者们认为,非编码RNAs似乎不仅可以作为脓毒症肺损伤的诊断标志物,而且可以作为其治疗靶点.该文将从非编码RNAs的产生和作用机制等方面,对非编码RNAs在脓毒症肺损伤中参与的作用及应用进行综述.%Non-ceding RNAs refer to a class of RNA molecules that do not have the function of coding proteins,mainly include microRNAs,long non-coding RNAs and cireular RNAs.Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection,which attacks the lung first.Recent studies have found that these non-coding RNAs,especially microRNAs,can regulate gene expression at various levels such as gene transcription,RNA maturation and protein translation,leading to the release and activation of proinflammatory and inflammatory mediators,the injury of vascular endothelial,and finally cause the lung injury.Researchers believe that non-coding RNAs appear to be not only diagnostic markers but also therapeutic targets for sepsis-induced acute lung injury.In this paper,the role and application of non-coding RNAs in sepsis-induced acute lung injury will be reviewed from their production and mechanism.