Circadian clock, which is also known as circadian rhythm is the cyclical fluctuation of biological behavior and physiological phenomena in organism. Recently, studies on the molecular mechanism of circadian clock generation and synchronization were increasing. Results showed some diseases (e.g., insomnia, cancer, depression, Alzheimer's disease etc.) are related to the periodic variations of circadian clock. Therefore, the studies on the relationship between the periodic variations of circadian clock and some related diseases have important implication. In this article, the studies on the physiological mechanism of circadian clock and related diseases were summarized, which could provide theoretical basis for the researches on circadian clock and the controls of related diseases.%生物钟又称生物节律,是生物体内周期性波动的行为和生理现象,近年来对生物钟产生和同步的分子机制的研究日益深入.研究表明,生物钟的周期性变化与生物体的某些疾病(如失眠、癌症、抑郁症、阿尔茨海默氏病等)息息相关.所以,对生物钟与相关疾病的关系的研究有重要的意义.本文就国内外有关生物钟的生理机制及生物钟相关疾病的研究综述如下,以期为更好地研究生物钟的生理机制及防治相关疾病提供理论依据.
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